Associate Director,
In Vivo Pharmacology

At Kestrel our aspiration is to invent brilliant technologies and develop novel small molecule agents for cancer targets of exceptional scientific and clinical import, beginning with mutant RAS. Our reliance is on the rigorous application of innovative science in the service of the discovery of new medicines for people with cancer. Our priority is patients, always.

Kestrel is an oncology biotech start-up in its early stages of growth, having been in operation since January of 2022. We have excellent funding and, having moved into our new laboratory space in early 2023, are in the process of expanding our team.

We are seeking an outstanding individual to lead our In Vivo Pharmacology function. The candidate should be an experienced In Vivo Pharmacologist with a strong track record of delivering in vivo data packages in support of oncology development candidate nominations and IND filings.

The successful candidate will assume the role of Associate Director, In Vivo Pharmacology reporting directly to the Vice President of Biology.

Key Responsibilities

  • Serve as the In Vivo Pharmacology Lead on Project Team passionate about developing small molecule modulators of validated oncology targets
  • Direct the design, execution, and analysis of in vivo pharmacology studies via external partnerships (e.g., CROs and academic collaborations)
  • Identify and / or develop clinically-relevant mouse models (C/PDX, etc.) of target indications
  • Generate comprehensive in vivo data packages, comprising PK-PD, efficacy, and tolerability, for IND filings, efficacious human dose predictions, and to inform clinical trial design
  • Identify and / or develop assays for assessment of tractable PD and predictive biomarkers
  • Maintain records (including study protocols, procedures, data reports, and related documentation) and prepare reports for regulatory filings
  • Work collaboratively with chemistry and biology colleagues to ensure timely generation and dissemination of critical program data to enable decision-making and milestone progression

Professional Experience & Qualifications

  • Ph.D. in pharmacology, biology, cancer genetics or related field
  • 7+ years of relevant biotech or pharmaceutical industry experience
  • Technical expertise in in vivo oncology /pharmacology approaches including animal handling & monitoring, tumor implantation (subcutaneous, disseminated, orthotopic), tumor measurement / imaging, dosing (IP, IV, SC, PO), blood / tumor sampling & biospecimen preparation / storage
  • Deep knowledge of mouse models of cancer (e.g., CDX, PDX, syngeneic, and GEMMs)
  • Strong track record of delivering in vivo pharmacology data packages in support of development candidate nominations and IND filings
  • Experience managing junior scientists, external CROs and collaborations
  • Excellent written / verbal communication, organization, and time management skills

Kestrel Therapeutics offers a generous benefits package including medical, dental, vision, and disability insurance, as well as paid time off and a 401k plan.

Kestrel Therapeutics is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, ethnicity, color, national origin, religion, age, marital status, veteran status, disability, genetic information, sexual orientation, gender identity or any other basis protected by federal, state, or local law.

Apply Now

Fill out the form below and we will contact you.

Please upload your resumé.