Associate Director, Computational Chemistry
At Kestrel our aspiration is to invent brilliant technologies and develop novel small molecule agents for cancer targets of exceptional scientific and clinical import, beginning with mutant RAS. Our reliance is on the rigorous application of innovative science in the service of the discovery of new medicines for people with cancer. Our priority is patients, always.
Kestrel is an oncology biotech start-up in its early stages of growth and has been in operation since January of 2022. We have excellent funding and, having moved into our new laboratory space in early 2023, are in the process of expanding our team.
We are seeking an outstanding individual to lead our computational chemistry activities. The candidate should be a self-motivated and influential leader with a strong record of accomplishment in applying computational tools in drug discovery. Proven ability to develop and effectively implement in silico modeling is required as is the ability to excel in a collaborative multidisciplinary environment.
The successful candidate will assume the role of Associate Director of Computational Chemistry and will report directly to the Vice President of Medicinal Chemistry.
Key Responsibilities
- Working closely with the medicinal chemistry team on multiple small molecule drug discovery programs using structure-based drug design
- Develop and implement computational models for protein-ligand binding to support ongoing programs and new target selection
- Plan, execute, interpret, and optimize structure activity relationship campaigns
- Build and maintain productive relationships with external collaborators in computational chemistry and cheminformatics
- Ability to clearly and effectively communicate project updates to key stakeholders
Professional Experience & Qualifications
- Ph. D. in Computational Chemistry or related field with 5+ years of experience working in a pharmaceutical / biotechnology setting as a computational chemist
- Expertise in molecular dynamics simulations, molecular modeling and related methods, such as enhanced sampling and binding free energy predictions
- Experience with various molecular modeling platforms (MOE, Schrodinger suite, etc.)
- Strong programming skills in Python or other scripting languages
- Demonstrated leadership in computational chemistry and drug discovery as evidenced by a strong record of scientific accomplishment and cross-functional collaboration
- Experience working with AI/ML methods in drug discovery is preferred
- Excellent written and oral communication skills
Kestrel Therapeutics offers a generous benefits package including medical, dental, vision, and disability insurance, as well as paid time off and a 401k plan match.
Kestrel Therapeutics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, ethnicity, color, national origin, religion, age, marital status, veteran status, disability, genetic information, sexual orientation, gender identity or any other basis protected by federal, state, or local law.
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